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As previously referred, this loop is fed by melanocytes OS, which leads melanocytes to secret DAMPs and stimulating IFN- production, a pivotal cytokine to recruit and guide recirculating CD8 + T cells to melanocytes via IFN-CXCL9/10CXCR3 axis (Figure 1)

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A comprehensive metabolomics and transcriptomics study investigating bioenergetics, including brain and plasma acylcarnitines, in 16 months old APOE3-TR and APOE4-TR mice found increases in FAO in E4s especially in females (Shang et al., 2020)