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This can be linked to a significant reduction of serine palmitoyl transferase (SPT) protein levels and the downregulation of the ceramide-synthesis enzymes ceramide synthase 5 ( CERS5 ) and delta(4)-desaturase as well as sphingolipid 1 ( DEGS1 ) expression at both messenger-RNA and protein levels
Kameoka J, Tanaka T, Nojima Y, Schlossman S, Morimoto C (1993) Direct association of adenosine deaminase with a T cell activation antigen, CD26
Both these receptors are activated by similar types of short chain fatty acids (292), and both these signal through an inhibitory G type protein, but FFAR2 is also capable to signal through Gq/11 proteins (293) by which it has shown to mediate GLP-1 and PYY secretion in vitro and in vivo (82, 295)
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