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The only literature-reported phase 1 clinical study to date was recently conducted with PF-06882961
May administer without regard to food Kidney disease No dose adjustment is necessary for any degree of renal impairment Liver disease No dose adjustment is necessary for any degree of hepatic impairment Generic / Price NO/$$$$ Storage Unused pens Keep refrigerated Good until expiration date Do not freeze After first dose Store at room temperature or refrigerated Good for 56 days Semaglutide Rybelsus Rybelsus Dosage forms Tablet (formulation R1) 3 mg 7 mg 14 mg Tablet (formulation R2) 1.5 mg 4 mg 9 mg Dosing Type 2 diabetes (formulation R1) Starting (Day 1 to 30): 3 mg once daily for 30 days (this dosage is not effective for glycemic control) Escalation and Maintenance Dosage: Days 31 to 60: Increase the dosage to 7 mg orally once daily Day 61 and on: If blood sugars are controlled, continue 7 mg once daily
Data were analysed using FlowJo (v9) software
Eur J Endocrinol 181(6):R211R234 Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V et al (2021) A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
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