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The SHMT1 encoded enzyme is cytosolic and the SHMT2 encoded enzyme is mitochondrial
After being converted to glutamate (Glu) by the enzyme glutaminase (GLS), Gln is further transformed to -ketoglutarate (-KG), entering the mitochondrial tricarboxylic acid (TCA) cycle for energy production
Available at: Copyright 2006
Intestinal microbiota interact with gut-associated lymphoid tissue to maintain host defenses and immune tolerance, which are implicated in autoimmune disease
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