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It should ease as your body gets used to the treatment
Results vary based on diet, sun exposure, and metabolism
I think an important question for individuals though is: if I want to go off these medications let's say I can't afford them anymore, I just want to get off them, I don't like taking them anymore, nor do I want to switch to the pill, which two pills are now available how do I keep my weight off knowing there's a metabolic adaptation
A 2024 systematic review of GLP-1 receptor agonists and oral medications concluded that dose adjustments are probably not needed in most cases, though the authors flagged drugs with a narrow therapeutic index for closer attention
