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The FOXO family is involved in regulating critical processes such as stress resistance, metabolism, cell cycle arrest, and apoptosis (Martins et al., 2016)
1.2 10 5 SHSY-5Y cells were subjected to similar treatment as above except 1 mM MPP + (for 24 h) was used to induce ROS
Instead of genetic knockout, functional knockout of FoxO1 occurs naturally when -cells undergo LOsG/ROS stress
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