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Front Cell Neurosci 13:496

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Key Takeaways Topical peptides (especially GHK-Cu): Well-supported by human clinical studies for skincare

At the gene level, GHK-Cu modulates a large share of the human transcriptome: an influence on roughly 31.2 percent of genes at a change of at least 50 percent is reported, of which about 59 percent are upregulated and 41 percent downregulated, with upregulation of about 84 DNA repair genes and ubiquitin-proteasome genes as well as suppression of proinflammatory signals such as IL-6 and NF-kB-driven TNF Pickart et al., 2018