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Chromatography was performed at ambient temperature with flow rate of 0.7 ml min 1 with linear gradient from water (0.05% TFA): MeOH (0.05% TFA) [95:5] to water (0.05% TFA): MeOH (0.05% TFA) [5:95] over 15 min and resolved peaks were detected by a 2998 photodiode array (PDA) detector at 215 nm
The specific lot number, testing laboratory, and measured values appear on that lots COA (detailed below)
subpotent drugs
Mechanistically, E4s primary effect was to alleviate inflammatory responses and vascular abnormalities, with relatively modest inhibitory effects on VEGF [62]
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