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Unlike the CBV response to 5-second stimulation, triphasic responses were observed with longer stimulation
Topical glutathione often works synergistically with other skin-brightening ingredients like vitamin C, providing enhanced benefits when used in combination
Similarly, ERK (extracellular signal-regulated kinase) and its involvement in melanin synthesis via the ERK/CREB (cAMP response element binding protein) pathway demonstrate how kinases contribute not only to antioxidant defense but also to pigmentation regulation by upregulating MITF and TRP1 69,71
[17] Estrada-Reyes R, et al
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