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Unlike metformin, which has a well-established association with vitamin B12 malabsorption through interference with calcium-dependent B12-intrinsic factor complex absorption in the terminal ileum, there is no official link between GLP-1 receptor agonists and direct B12 depletion
By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways
While all significant weight loss results in some loss of lean tissue (muscle), studies show that the majority of weight loss is from body fat
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