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Description

Evidence for antifibrotic incretin-independent effects of the DPP-4 inhibitor linagliptin

Muscle and glucose control

A public meeting on ICERs draft report is scheduled for November, after which a final version will be released

Since it has been reported that GLP-1 receptor expression level in pancreatic -cells is down-regulated by lipotoxicity such as free fatty acids (FFA) and/or triglyceride (TG) both of which are usually high in obese subjects, we assume that FFA and TG are possible parameters involved in arterial GLP-1 receptor and TCL7L2 levels

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