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The first word corresponds to the gene (being replaced or corrected) and the second word corresponds to the vector (the backbone of the gene therapy product)

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DNA methylation can affect therapeutic responses through various mechanisms, including affecting membrane transport, DNA repair, signaling pathway activity and apoptosis [158]

Specifically, attenuation of MAPK pathway activation may contribute to the reduction of inflammatory and stress responses following irradiation, whereas regulation of Rap1-associated signaling may be involved in the maintenance of adherens junction-related proteins, including -catenin and E-cadherin, thereby supporting intestinal barrier integrity