Further studies aimed at elucidating the exact mechanisms underlying RSL3-induced DNA damage are needed
A 2013 study in Bangladesh looked at people exposed to different levels of arsenic in their drinking water
The COMBO-DN study - a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain
The atypical presentations that should alert the physician to consider non-diabetic causes of neuropathy via referral for a detailed neurological work-up (confirmatory tests) include: (1) asymmetry and rapid progression of the symptoms, (2) predominant motor weakness over sensory loss, (3) mononeuropathy or cranial nerve involvement, (4) progression of the neuropathy despite optimal glycemic control, (5) symptoms from the upper limbs, (6) family history of nondiabetic neuropathy, (7) severe painful symptoms in the feet whilst clinical examination is normal, 8) diagnosis of DPN cannot be ascertained by clinical examination with the semi-quantitative bedside tests (68, 20, 22, 74) ( Figure 1 )
