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It is approved for chronic weight management in adults with obesity or overweight with weight-related comorbidities, though clinical trials show promising effects on liver health as a secondary benefit
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FDA Commissioner Makary had also published a JAMA editorial accusing Hims of a breach of FDA regulation with its 2025 Super Bowl advertisement, which promoted weight-loss drugs without adequately disclosing side effects
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist Text PDF Abstract Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis
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