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GLP-1 drugs like Ozempic act directly on hormone pathways: they mimic the glucagon-like peptide-1 hormone, which slows stomach emptying, reduces appetite, and boosts insulin secretion from the pancreas
& Bhonde, R
172,173,174 This represents a major advance as the first successful PROTAC-mediated degradation of an ER-localized, polytopic transmembrane protein, opening new possibilities for metabolic intervention
Perhaps, the disease can be regulated by blocking different antioxidant systems during neoadjuvant treatments
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