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Ferroptosis in other tissues and organ remodeling Regulatory mechanism of ferroptosis in vascular remodeling diseases Suboptimal spiral artery remodeling in preeclampsia (PE) PE is a placenta-associated disease characterized by hypertension with the damage to maternal end organs, and is one of the major contributing factors to both maternal and fetal mortality and morbidity [117]

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In particular, potential barrier disruptors such as hypoperfusion of the gut, infections and toxins, but also selected over-dosed nutrients, drugs, and other lifestyle factors have to be considered