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Both medications may increase the risk of pancreatitis, gallbladder problems, and kidney issues
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In contrast, orforglipron employs a chemically stable scaffold that preserves receptor affinity while allowing gastrointestinal persistence and predictable systemic exposure
In chronic liver disease, this could be expressed through significant reduction of clinical outcomes such as the development of cirrhosis and its complications (ascites, hepatic encephalopathy, gastrointestinal hemorrhage), as well as all-cause mortality 7
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