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Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS (ALCALS) 2025
Multiple clinical trialsincluding SUSTAIN-6 (semaglutide) and REWIND (dulaglutide)showed significant reductions in major adverse cardiovascular events (MACE) such as: Heart attack Stroke Cardiovascular death This benefit appears to be independent of weight loss , suggesting direct protective effects on the arteries, blood pressure, and cholesterol metabolism
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This could be explained by the fact that longitudinal smooth muscles contractions cause increase in its length 26 these contractions improve gastric emptying and provide proper food mixing
