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Directly attacking DNA, H 2 O 2 /O/OH/ 1 O can cause DNA strand breakage and disrupt DNA damage repair pathways [210]
The class divides into GHRH analogs (sermorelin, tesamorelin, CJC-1295) and ghrelin mimetics (ipamorelin), with AOD-9604 as a mechanistically distinct fragment
Since ROS-dependent DNA damage is markedly increased in myeloid cells after Bcr-Abl transformation 18 , we hypothesize that blocking dTTP and dCTP supply might exacerbate replication stress and DNA damage in Bcr-Abl-transformed cells, thereby jeopardizing cell survival
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