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While you can supplement with a bit more than this (many supplements have 15 to 30 mg), you should not exceed the tolerable upper intake of 40 mg per day from food and supplements combined, unless supervised by a doctor
Nothing in the trial record addresses dose-doubling, and the pharmacokinetics argue directly against it
Cefalu et al
Cell (2004) 118(2):22941.10.1016/j.cell.2004.07.002 146 WorthingtonJJSamuelsonLCGrencisRKMcLaughlinJT
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