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Compared to younger cells, SnCs exhibit elevated expression of anti-apoptotic proteins such as the B cell lymphoma-2 (BCL-2) family members and heightened activity of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway

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Conclusions This preclinical study suggests that folate may facilitate CRC progression and immune evasion by impairing CD8 + T cell recruitment and anti-tumor activity