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Losing muscle: Reduces metabolic rate , making it harder to maintain weight loss Increases frailty , especially in older adults Raises the risk of chronic conditions like diabetes, heart disease, and osteoporosis The rise of GLP-1 receptor agonists (e.g., semaglutide and tirzepatide) has amplified this concern

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at proximity of hepatocytes replicating HBV, could be strong, whereas long distance inhibition (systemic) could be lower