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Koehler (47) reported that GLP-1RAs may induce apoptosis by altering cell morphology in vitro , possibly by activating cAMP expression and inhibiting the activities of the signaling kinases glycogen synthase kinase 3 and ERK1/2, thereby inducing apoptosis and inhibiting the growth and survival of colon cancer cells
The EMA notes that about 1 in 10,000 Ozempic patients may experience this rare side effect
Prescribers should also consider whether the benefits of concurrent use outweigh the risks, and whether alternative treatment strategies might be more appropriate for the individual patient
Obesity is the biggest risk factor for Type 2 diabetes, and substantial weight loss can help in reversal and remission of the disease, as well as reduced risk for conditions like high blood pressure, dyslipidemia, heart disease, and stroke
