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The diagnosis of 5-oxoprolinase deficiency is established by: Low activity of 5-oxoprolinase in nucleated cells such as leukocytes or cultured skin fibroblasts (5-oxoprolinase is not present in erythrocytes)

Laboratory tests will include: Standard blood tests to measure the level of red blood cells and check their appearance

Patch Test First Before applying to larger cosmetic application areas: Apply a small amount to the inner arm or jawline Wait approximately 24 hours Discontinue cosmetic use if irritation occurs Recommended Strength Guide For most cosmetic formulations, 1% is commonly utilized as an introductory concentration

A study in a respected medical journal found that the Vitamin B12 type chosen can greatly affect treatment success