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MRI-guided histology of TDP-43 knock-in mice implicates parvalbumin interneuron loss, impaired neurogenesis and aberrant neurodevelopment in amyotrophic lateral sclerosis-frontotemporal dementia

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Potentially deleterious reactive oxygen species (ie, superoxides, peroxides, and hydroxyl radicals) are produced during the oxidation of fuels (oxidative phosphorylation) in mitochondria as byproducts of the utilization of molecular oxygen in the electron transport chain