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Third, clinical translation should include establishing multicenter ALS biobanks to validate associations between biomarkers such as ACSL4 and GPX4 and clinical measures including ALSFRS-R scores and survival, and conducting combined trials of ferroptosis inhibitors with mitochondrial protectants to evaluate therapeutic benefit in sporadic ALS

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(2015) European Neuropsychopharmacology , 25(12): 22162225 Examined neural and cognitive processing following ARA-290 administration in human volunteers, providing early evidence of ARA-290s CNS modulatory properties and cognitive relevance

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