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Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and cardiovascular diseases
Although such interactions remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of Janumet and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system
Most people who see changes notice improvements in: Systolic blood pressure (the top number) Diastolic blood pressure (the bottom number) These changes tend to occur gradually as the body adapts to metabolic improvements rather than immediately after starting treatment
The risk of weight gain and hypoglycemia can also be reduced with this combination therapy
