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In terms of hypos, there were 1.8 hypos per patient years in users of IDegLira compared 2.6 for users of Tresiba and 0.2 for users of Victoza
Studies have shown that GLP-1 treatment significantly increases the expression levels of BTG2, Pdx1, and the insulin gene in pancreatic cells, indicating that GLP-1 positively regulates insulin gene expression through BTG2, thereby promoting insulin synthesis (Hwang et al., 2013)
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DARPins can selectively bind any given target protein with high affinity 30 , and HSA can be specifically targeted by albumin-binding DARPin too
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