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The study also hypothesized the role of the NO-cyclic GMP-dependent pathway in relation to the melanocortin agonists-induced increases in cavernosal pressure

Anti-inflammatory properties: Reduces chronic low-grade inflammation, which causes skin thinning, loss of suppleness, and age-related tissue breakdown

"This could create a niche where these agents outperform pure GLP-1RAs," says Nadolsky

For patients who are not candidates for GLP-1-RAs and have a contraindication to topiramate (e.g., nephrolithiasis) and/or phentermine (e.g., uncontrolled hypertension), monotherapy bupropion or bupropion/naltrexone might be considered, though little data exists regarding its efficacy after bariatric surgery