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As 2nd line therapy, ivabradine, vericiguat or ARB (angiotensin receptor blocker) can be chosen in patients with insufficient response to the treatment or in the case of adverse effects of 1st line medications (125)

Study Objectives To evaluate if semaglutide 2.4 mg subcutaneously once weekly is superior to placebo when added to standard of care for preventing major adverse cardiovascular events in patients with established CVD and overweight or obesity but without diabetes

Many patients continue compounded injections or switch to oral formulations ($289 per month) for convenience