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This model would also be consistent with the reported potentiation of insulin release by GLP-1R biased-agonists that trigger a reduction in -arrestin recruitment [45, 68,69,70]

A 12-h day/night cycle allows the animals to maintain a normal circadian rhythm, with free access to food and water

381 Bright light therapy is sometimes combined with one day of sleep deprivation followed by several days of structured early bedtimes and waketimes

Rafael Gutirrez , especialista en adicciones por la Universidad de Santiago de Chile, plantea la importancia de considerar una intervencin teraputica ms integral, complementado la farmacologa con sesiones de psicoterapia especializada, para tener un manejo ms estandarizado de esta enfermedad