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Big losses of 7 to 14 kg (15 to 30 pounds) or more within months tend to cause even more defined shifts, including sunken cheeks, pronounced nasolabial folds, sagging along the jawline, and sharper bone structure
GLP-1 receptor agonists significantly lowered CRP levels (standardised mean difference of 0.39) and TNF- levels (SMD of 0.51), with longer treatment durations yielding more noticeable benefits, according to a thorough meta-analysis published in 2025 that synthesised 25 studies involving 1,878 patients with type 2 diabetes
Nat Commun 13(1):2003
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