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Bucillamine was shown to be safe in humans but not tested yet for the reduction of oxidative stress in the respiratory system of patients [81]
Bacos K, Perfilyev A, Karagiannopoulos A et al (2023) Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets
Sex had a moderating effect on the meta-analysis outcome and is reasonable since it was known that the male-to-female ratio was 4:1 for ASD 4
The main efficacy-related conclusions of this review are: (a) medications demonstrated the strongest and most consistent effects on core ADHD symptoms (especially inattention), (b) heterogeneous C/BTs demonstrated inconsistent effects on ADHD symptoms, strong consistent effects on impairment and executive function skills, and modest consistent effects on internalizing symptoms and analogue note-taking performance, (c) C/BTs demonstrated consistent maintenance effects for executive function skills and impairment up to 6 months and possibly 3 years post-treatment, (d) though comparing the efficacy of two C/BTs rarely led to significant differences, which C/BT worked best for whom could be reliably predicted from patient- and provider-level moderators
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