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Transplantation of faecal microorganisms (FMT) from healthy mice into male mice placed on a high-fat diet (HFD) can restore bacterial diversity, improves metabolism associated with poor dietary patterns and reduces hippocampal astrocyte hyperplasia, supporting the role of ecological dysregulation in mediating obesity-induced cognitive impairment (60)

The mechanism sits upstream of anything you can feel: blocking NNMT stops nicotinamide being methylated into 1-MNA, which raises intracellular NAD+ and SAM and suppresses fat-cell lipogenesis

ACT-AD Trial: Phase 2 Failure The ACT-AD phase 2 trial enrolled Alzheimer's patients and tested fosgonimeton efficacy on cognitive decline