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In controlled research environments, GHK-Cu is commonly used to study: Skin and connective-tissue repair processes Fibroblast recruitment, proliferation, and matrix production Angiogenesis and endothelial-cell behavior Antimicrobial activity in wound models (when combined with selected co-factors) Neurobiological and gene-expression changes in nervous system models Experimental modulation of inflammatory and fibrotic responses These applications make GHK-Cu a versatile tool for probing how small copper-peptide complexes participate in tissue-regeneration and stress-response pathways
However, the clinical advancement of oridonin faced limitations [24, 25], stemming not only from its unclear molecular mechanisms but also due to hydrophobicity and deficient targeting capabilities [26,27,28,29]
This characteristic makes dihexa a compelling subject for ongoing and future research in neuropharmacology