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Furthermore, cyanocobalamin is a synthetic form of cobalamin used in treating vitamin B 12 deficiency
When treated with 5FU, cancer cells specifically increase mitochondrial content to buffer nucleotide stress, whereas stromal cells do not, meaning that cancer cells become intrinsically more dependent on mitochondrial metabolism
its function depends on the ATP-driven chaperone cycle and requires cooperation with HSP40 co-chaperones and nucleotide exchange factors (NEFs), which regulate substrate binding and release, promote correct protein folding, and prevent protein aggregation (Maugeri et al., 2010)
The amounts used topically or in injectable protocols are tiny compared to dietary copper intake
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