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Notably, no signal for ION was detected with tirzepatide, a dual GLP-1/GIP receptor agonist used for diabetes and obesity, and comparator drugs such as metformin and insulin also showed no significant associations
However, comprehensive semaglutide training for physicians is strongly recommended for safe and effective prescribing
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Potential benefit - A patient whose biomarkers suggest rapid metabolism of GLP-1 drugs might be offered a longer-acting formulation, while someone with strong GIP responsiveness could start on a dual-agonist right away, avoiding months of trial-and-error
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