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This doesn't mean it's unsafe it means it hasn't gone through the specific regulatory pathway the FDA requires for approved drugs
The enzyme responsible for degrading excess norepinephrine and adrenaline is called COMT (catechol-O-methyltransferase)
(2010) Effect of physiological doses of oral vitamin B12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India
Researchers should confirm that: No
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