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10.3390/antiox11050965 Antioxidants
On one hand, ROS-mediated damage to the cystine-glutamate antiporter SLC7A11expressed on RMECs, RPE cells, and Mller cellsimpairs cystine-cysteine biotransformation, disrupts the GSH- GPX4 antioxidant axis, and thereby triggers ferroptosis in these cell populations
Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)
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