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Why GLP-1s Are Revolutionary: Historical Context: Before GLP-1 medications: Weight loss medications produced 3-7% average weight loss Only bariatric surgery achieved 15-30% weight loss Many people couldnt access surgery due to cost, risk, or preferences Gap existed between ineffective pills and invasive surgery GLP-1s filled this gap: Producing 10-22% weight loss with medication alone Non-surgical option with bariatric-level results Relatively few contraindications Once-weekly administration Generally well-tolerated How GLP-1 Medications Work: Natural Hormone Mimicry: GLP-1 is a hormone your body naturally produces in your intestines after eating
Rare but serious risks include pancreatitis, gallbladder problems, and thyroid C-cell tumors (observed in animal studies, clinical significance in humans unclear)
Peptides are naturally occurring in the body and consist of amino acids, which are the building blocks of proteins
Petrenko V, Jayanna P
