[8] It is also available in the fixed-dose combination medication sitagliptin/metformin (Janumet, Janumet XR)
doi:10.1016/j.fm.2010.08.011 Masi, A., Ghisi, R., & Ferretti, M
More specifically, GLP-1R expression has been identified in several hypothalamic and basal forebrain regions, including the paraventricular nucleus, supraoptic nucleus, infundibular nucleus/arcuate nucleus, lateral hypothalamic area, and nuclei of the basal forebrain, where they exhibit relatively well-defined regional expression patterns (43, 44)
For example, obesity and visceral fat accumulation showed positive association with DPN, and insulin resistance can be involved in this pathophysiology observed in T2DM [11]