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There was an increased number of thyroid cancers in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) clinical trial evaluating liraglutide versus placebo, but the risk did not reach statistical significance (hazard ratio [HR] 1.66, 95% CI 0.406.95), as well as in a meta-analysis of 12 other clinical trials with liraglutide (odds ratio [OR] 1.54, 95% CI 0.406.02) (7,8)
Maintaining a dose that you can be comfortable with is far more important than pushing to lose every additional pound
Personalized strategies that preserve muscle mass and support metabolic health align with reduced caloric intake, nutrient deficiencies, and rapid body composition changes associated with GLP-1s
Deanfield, S.E
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