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However, the H 2 O 2 -induced increases in PTGS2 , SLC7A11 , and TNF mRNA, surface expression of the transferrin receptor, and lipid peroxidation are features that accompany ferroptosisan iron-dependent form of cell death
It plays a critical role in the synthesis of myelin, protecting nerve fibers and ensuring efficient nerve signal transmission
For this reason, First-in-Human trials are not only a procedural milestone in drug development
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