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Individual safety findings for one molecule dont necessarily predict class-wide effects, says Finer, safety signals often relate to specific structural features or off-target activities rather than the primary mechanism of action. He thinks oral GLP-1 drugs have the potential for better dose titration, which might help control the current, mainly gastrointestinal, side-effects of the injectable peptides

Increased risk of diabetic retinopathy complications in patients with a history of the condition

But no one's directly tested in people with arthritis doing cold exposure and then measure their actual levels, which that would be a good study to do, but it just hasn't been done

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