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Additionally, patients who are exposed to environmental oxidative stress or suffer from genetic deficits (such as methylation pathways) would have more favorites results by related nutrient supplementation, compared with other subjects

Abbreviations BMP15: Bone morphogenetic protein-15 BNC1: Basonuclin 1 CPEB3: Cytoplasmic polyadenylation element-binding protein 3 DEHP: Di-(2-ethylhexyl) phthalate DOR: Diminished ovarian reserve DSBs: DNA double-strand breaks EDCs: Endocrine disrupting chemicals ETs: Environmental toxicants GCs: Granulosa cells HRT: Hormone replacement therapy IVA: In vitro activation MSCs: Mesenchymal stem cells PM: Particulate matter POI: Premature ovarian insufficiency RPR: Platelet-rich plasma ROS: Reactive oxygen species TMCO1: Transmembrane and coiled-coil domains 1 VCD: 4-vinylcyclohexene diepoxide References European Society for Human R, Embryology Guideline Group on POI, Webber L, Davies M, Anderson R, Bartlett J, et al

Statistical significance was assessed by two-tailed unpaired t-test in g-I, s, t

The geroscience hypothesis proposes this principle but necessitates experimental testing