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In this context, GLP-1R agonists have been shown to affect the central nervous system and exhibit neuroprotective properties in animal models of several neurodegenerative diseases, including Alzheimers and Parkinsons disease, stroke, diabetic retinopathy, and ocular hypertension (McClean et al., 2011
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This strategic positioning ensures optimal spacing between the peptide backbone and the lipidation element while maintaining receptor accessibility
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