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Recuperato da: Petroni ML, Montesi L, Colosimo S, Caletti MT, Mazzotti A, Marchesini G

Further supporting the notion of glucose dependent metabolic switching after drug treatment, p53 + colorectal cells surviving treatment with irinotecan, a topoisomerase-1 inhibitor, had increased oxphos (Marx et al., 2022)

For example, if you started a GLP-1 in September 2024 with a BMI of 37, but in July 2026 you've lost weight and now have a BMI of 34, the prescriber should attest in the prior authorization request that you met the BMI criteria of 35 or over when the GLP-1 therapy started

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