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The PDEs, particularly PDE1B and PDE10A, are abundant in the CNS (Table 1) and exert a crucial influence on the modulation of cyclic nucleotide signaling (Figure 1) (Lakics et al., 2010
However, traditional oral glutathione has limited bioavailability due to breakdown in the digestive system
Psychiatry 56 , 638643 (1993)
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