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Following the fourth cycle, a single test session was conducted using a dose of 0.003 mg/kg semaglutide, included in the acute dose response curve to evaluate whether a lower dose might fall below the threshold required to alter alcohol discrimination (Fig

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In the dextran sulfate sodium (DSS) colitis model, the liraglutide group had significantly lower cecal occludin mRNA levels and significantly higher TNF- mRNA levels compared with the control group, with no difference in body weight (Fig

Oral dosing relies on the peptide surviving stomach acid and GI enzymes, which reduces bioavailable fraction