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In a phase 1 trial, a PYY analogue (Y14 peptide) administered subcutaneously at 7- to 14-days intervals was safe and potentially efficacious (WL between 2.9 and 3.6 kg at 31 days, with a 3855% reduction in food intake vs
GLP-1 agonists were on the market in 2005 with exenatide
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But decades of research have revealed a far more complex picture, one involving at least five interconnected systems that all contribute to mental health dysfunction
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